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Healthcare professionals

VisuXL®

VisuXL® is a preservative-free eye drop treatment for dry eye disease and for aiding recovery following eye surgery.

VisuXL® contains two unique ingredients in one effective solution

Cross-linked hyaluronic acid

  • VisuXL®‘s cross-linked HA forms a stable liquid matrix on the surface of the eye. A study in an animal model demonstrates that the cross-linked formula has a residence time which lasts three times longer than linear HA1
  • Patients can experience dry eye relief from two drops per day2

CoenzymeQ10 (COQ10)

  • CoQ10 belongs to a family of compounds known as ubiquinones and is present in all eukaryotic species3
  • CoQ10 has a role in:4,5
    • Mitochondrial energetics: production of ATP
    • Protection to the mitochondrial and lipid membranes against oxidative damages as an effective antioxidant/free radical scavenger
    • Regulation of apoptosis through free radical scavenging and non-free radical scavenging mechanisms

Held in place by the cross-linked HA liquid matrix VisuXL®’s CoQ10:

  • Accelerates ocular surface healing following cataract surgery compared to usual care in a randomised clinical trial7
  • Plays an essential role in mitochondrial function6,9
  • Demonstrated healing in refractory ulcers in a case series6
  • Protects against surgery related damage (in animal model)8

VisuXL® contains2 cross-linked hyaluronic acid sodium salt 0.1%, Coenzyme Q10 0.1%, Vitamin E (D-alpha-tocopheryl-polyetheylene glycol 1000 succinate) 0.5% and buffer isotonic solution.

References

  1. Muzzi M & Mencucci R. In vivo comparison of the residence time of cross-linked compared to linear hyaluronic acid in rabbit eye. Association for Ocular Pharmacology and Therapeutics (AOPT) 13th Scientific Meeting, Feb 16-19 2017, Florence Italy. Poster
  2. VisuXL® Instructions for Use, VISUfarma.
  3. Wang Y & Heikimi S. Understanding Ubiquinone. Trends in Cell Biology. 2016; 26 (5);367-378.
  4. Mencucci R et al. CoQ10-Containing Eye Drops Prevent UVB-Induced Cornea Cell Damage and Increase Cornea Wound Healing by Preserving Mitochondrial Function. IOVS 2014;55(11):7266-7271.
  5. Papucci L et al. Coenzyme Q10 Prevents Apoptosis by Inhibiting Mitochondrial Depolarization Independently of its Free Radical Scavenging Property. Journal of Biological Chemistry. 2003;278(30):28220-8.
  6. Gumus K. Topical Coenzyme Q10 Eye Drops as an Adjuvant Treatment in Challenging Refractory Corneal Ulcers: A Case Series and Literature Review. Eye & contact Lens 2017;43 (2);73–80.
  7. Fogagnolo P et al. The Effects of Topical Coenzyme Q10 and Vitamin E D-a-Tocapheryl Polyethylene Glycol 1000 Succinate after Cataract Surgery: A Clinical and in vivo Confocal Study. Ophthalmologica. 2013;229(1):26-31.
  8. Brancato R et al. Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits. J Refractive Surgery 2002;18:135–139.
  9. Chen CC et al. Coenzyme Q10 Reduces Ethanol-Induced Apoptosis in Corneal Fibroblasts. PLoS ONE (6)4:e19111.doi:10.1371/journal.pone.0019111

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